The purpose of this activity is to provide pharmacy technicians and pharmacists with the information and skills for the use of pharmacogenomics when initiating and managing immunosuppressive medications in solid organ transplant recipients. Variations in an individual’s genes can affect drug response, especially with the pharmacokinetics and pharmacodynamics of medications used in maintenance immunosuppression that have a narrow therapeutic index. Based on specific phenotypes, therapy plans for transplant immunosuppression can become more personalized to each patient. This will assist in avoiding harmful adverse effects and toxicities, as well as reaching therapeutic outcomes.