Is the Weight Finally Over? Evaluation of Fixed-Dose versus Weight Based Dosing Strategies of 4-Factor Prothrombin Complex Concentrate
This presentation is intended to provide evidence based information to pharmacists and technicians at ChristianaCare regarding dosing strategies for 4-F PCC. Currently our institution doses 4-F PCC based on the FDA approved strategy of patient weight and INR. The goal is to present literature surrounding a fixed dose alternative strategy in order to assess the safety, efficacy, and cost outcomes. I plan to discuss the pathophysiology surrounding warfarin reversal, the pharmacology of 4-F PCC, other similar agents such as fresh frozen plasma and 3-F PCC, and how to apply both dosing strategies clinically. By the end of this presentation, the information presented will enable the pharmacists to assess how fixed dosing could potentially fit into our practice here at ChristianaCare.
Target Audience
- Pharmacists
- Pharmacy technicians
Learning Objectives
Pharmacist learning objectives
- Summarize the pharmacology of 4-F PCC
- State the differences between fixed dosing and weight based dosing 4-F PCC
- Describe the efficacy and safety of each dosing strategy
- Apply the literature to clinical scenarios in practice
Pharmacy technician learning objectives
- State the differences between fixed dosing and weight based dosing 4-F PCC
- Summarize the differences between 3-factor prothrombin complex concentrates, fresh frozen plasma, and 4-factor prothrombin complex concentrates
Additional Information
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Available Credit
- 1.00 ACPE Pharmacist
- 1.00 ACPE Pharmacy Technician
- 1.00 General CEU – Attendance