The National Institute on Drug Abuse reports that more than 2 million Americans abuse opioids and that more than 90 Americans die by opioid overdose every day, on average. These mortality rates from fatal overdoses exceed the rates of deaths from motor vehicle accidents. Younger age, having a history of prescription diversion or drug substitution, doctor or pharmacy shopping, having a history of psychiatric conditions, or use of psychotropic medications are major risk factors for misuse and abuse. However, anyone who takes opioids is at risk of developing addiction, even after one dose. Healthcare provider opioid-prescribing patterns (e.g., higher daily dosage of opioids) further increase patients’ risk for abuse, addiction, and overdose. Opioid stewardship programs are coordinated programs that promote appropriate use of opioid medications, improve patient outcomes, and reduce misuse of opioids. These programs are continuing to be implemented in hospitals all across the US, with pharmacists as a lead role. By being integral members of care teams in acute-care settings, pharmacists are well positioned to manage medications; educate providers, patients, and their families on appropriate use of opioids; and decrease diversion. Slidell Memorial Hospital (SMH) does not currently have an opioid stewardship program. This presentation should give pharmacists a baseline knowledge of their roles and activities, if a program is ever to be implemented at SMH. The evidence will be applied to patient cases to assess learning.