Sedation depresses the awareness of the ICU patients to reduce their response to invasive procedures, lessens patient-ventilator dyssynchrony, prevents agitation, and decreases stress and oxygen consumption. Currently, at OMC, ketamine is mainly being used for refractory status epilepticus and pain control (or hyperalgesia) with available dosing guidelines and protocol. No standard dosing is available for other indications such as sedation in the ICU. It is not one of sedative options in the sedation order set. If the medical team needs a sedative alternative for those patients who cannot tolerate fentanyl, propofol, dexmedetomidine, or midazolam, it is imperative for the team and pharmacists to be aware of the benefits of adding ketamine in certain patient populations as well as dosing, administration, and monitoring of ketamine. This activity will provide pharmacists and pharmacy technicians with sedation protocols, ketamine dosing comparisons for different indications, ketamine administration standards, suggested dosing, and target population to use ketamine for sedation in the ICU.