This activity will briefly review the OVIVA and POET trials that directly assessed the partial use of oral antibiotics for the treatment of osteomyelitis and left-sided endocarditis vs remaining on IV therapy for the duration of therapy. It will also briefly review recent literature assessing the early transition to oral step-down therapy in the treatment of gram positive and gram negative bloodstream infections. It will address which clinical scenarios would be most appropriate for an early transition to oral therapy. In addition to covering the therapeutic appropriateness of oral antibiotic therapy for the treatment of severe infections, the presentation will review the pharmacokinetics of oral antibiotic agents in order to assess the appropriateness of certain oral agents over others. A brief discussion on the implications that this change in practice can have on antimicrobial stewardship and OPAT services will take place. This information will help pharmacists to decide when they can make an intervention to transition a patient to oral antibiotics for the treatment of these severe infections.